Calcium Pyrophospate Dihydrate Deposition Disease (CPPD), Knee


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Frontal and lateral views of the knee demonstrate cartilaginous and meniscal calcifications. Note relative absence of osteophytes along the medial and lateral compartments of the knee and large osteophyte along the patellofemoral joint. Weight bearing joint spaces are only minimally narrowed.


Relationship of chondrocalcinosis to various diseases of the joints and its association with systemic problems is subject of some debate. The 2012 edition of Arthritis in Black and White by Brower and Fleming goes as far as to say that “the only two diseases that have definite association with CPPD crystal deposition are primary hyperparathyroidism and hemochromatosis.” UpToDate accessed in August of 2019 discusses European League Against Rheumatism (EULAR) task force classification, which includes osteoarthritis associated with CPPD, differentiates acute from chronic form and uses such terms as “pseudogout,” “pseudo-RA,” and “pseudo-OA.”